Dr Calvin Tiengwe presents novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei.
Read the full paper published in PLOS PATHOGENS:
BioStruct-Africa and researchers from Karolinska Institutet, Stockholm, determined three crystal structures of human MGST2: holoenzyme with GSH, apoenzyme, and a complex with the substrate analog/inhibitor glutathione sulfonic acid (GSO3−), which together with biochemical and computational evidence reveal the molecular basis for one-third the sites reactivity of MGST2 catalytic mechanism.
Read the full paper published in Nature Communications:
BioStruct-Africa provided an appraisal of the high prevalence of antibiotic resistance by commensal Escherichia coli in community settings. Our findings will have important ramifications for public health policy design to contain the spread of antibiotic resistance in community settings.
Read the full paper published in Scientific Reports:
A timely research by BioStruct-Africa to raise awareness of the extent of antibiotic resistance crises in community settings and calls for urgent action to address this global health crisis, especially in the current situation of the emergence of pandemics, like the severe acute respiratory coronavirus disease 2019 (COVID 19) that has led to a surge in the use of antimicrobial drugs within the community through self-medication and chemoprophylaxis.
Read the full paper published in the Journal of Global Health Action:
Malaria remains a significant health, social, and economic burden, especially in sub-Saharan Africa. More than 405,000 people die each year, with an additional 228 million infected and approximately 2.7 billion US$ spent on resources for malaria. Here we present "The molecular basis for sugar import in malaria parasites"
Read the full paper published in NATURE:
BioStruct-Africa has been empowering Africa-based scientist through structural biology knowledge transfer and mentoring.
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Dr. Emmanuel Nji and others present: "Crystal structures of a Zea mays CMP-sialic acid transporter (CST) apo and in complex with CMP and functional assays of corn and human CSTs suggest how CMP-sialic acid is translocated across Golgi membranes".
Read the full article in: https://www.nature.com/articles/s41594-019-0225-y
Mama Ndi and others revealed: 1. Two forms of mitochondrial protein Kgd4 cannot be explained by alternative splicing, 2. Kgd4L derives from alternative initiation at an upstream UUG codon, 3. Both variants are imported into mitochondria and support assembly of KGDH and 4. Sequence context surrounding codons dictates their use as alternative start sites.
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Dr. Emmanuel Nji and others revealed, the ammonium transporter AmtB and the PII signal transduction protein GlnZ are required to inhibit DraG in Azospirillum brasilense.
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Membrane bilayers are made up of a myriad of different lipids that affect membrane proteins, but identifying those specific lipid requirements remains a challenge. Here Dr. Emmanuel Nji (CEO and Co-Founder of Biostruct-Africa) and others present an engineered thermal-shift screen which reveals specific lipid preferences of eukaryotic and prokaryotic membrane proteins.
Stockholm University media release:
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"Conjugative transfer of antibiotic resistance plasmid pCW3 in Clostridium perfringens is mediated by the tcp locus. Here, Dr. Traore (Co-founder of Biostruct-Africa) and others identify a wHTH-type protein, TcpK, that is essential for efficient plasmid transfer and interacts with the plasmid oriT region in an unique manner."
Monash University, Australia media release:
Read the full paper in : https://www.nature.com/articles/s41467-018-06096-2